Effect of intraoperative administration of different doses of tramadol on pain in the early recovery period after remifentanil-based anesthesia

Objective:To compare the effects of 3 different doses of tramadol on pain in the early recovery period after remifentanil-based anesthesia. Methods:Sixty patients undergoing the operation on subabdominal tumor under remifentanil-based anesthesia were randomly assigned to receive intravenous injection of tramadol of 1.0 mg/kg in group Ⅰ,2.0 mg/kg in group Ⅱ,and 3.0 mg/kg in group Ⅲ 40 minutes before the end of the operation. The wake-up time,extubation time,and mean arterial pressure,heart rate,pain level evaluated by the Visual Analogue Scale(VAS),and incidence of complications within 20 minutes after extubation were recorded. Results:Compared to groupⅠ,the VAS pain scores were significantly lower in groups Ⅱ and Ⅲ(P 0.01),no significant differences in wake-up time,extubation time,and mean arterial pressure and heart rate after extubation were found. The incidences of nausea and vomiting in group III were higher than those in other 2 groups. Conclusion:The appropriate dose of tramadol is 2.0 mg/kg in the early recovery period after remifentanil-based anesthesia.