Compare of the effect of right ventricular apex pacing and mid-right ventricular septum pacing on left ventricular function and interleukin-6

Objective To study the influence of cardiac pacemaker implantation site on and left ventricular function and plasma interleukin-6(IL-6) . Methods Ninety-two patients with DDD or DDDR pacing were divided into three groups: right ventricular apex pacing group (RVA,n = 35) ,mid-right ventricular septum pacing group (mid-RVS ,n = 30) ,and control group(n = 27) . The plasma IL-6 level and left atrial diameter (LAD) ,left ventricular end diastolic diameter (LVEDD) ,left ventricular ejection fraction(LVEF) ,cardiac index(CI) of pre-operation and the sixth month of post-operation were tested . Results In the mid-RVS group and control group,no significant changes were abserved in plasma IL6 level ,LAD,LVEDD ,LVEF or CI from baseline to last follow-up. In the RVA group,plasma IL-6 level,LAD,LVEDD increased significantly at the sixth month(P 0. 05) . In the RVA group,LVEF and CI had down trends at the sixth month. Conclusion Mid-RVS pacing has less impact on plasma IL-6 level and left ventricular function. Mid-RVS is an ideal implantation site.[Chinese Journal of Cardiac Pacing and Electrophysiology,2013,27(2) : 142 - 144]