Changes of antithrombin and tumor necrosis factor-α in plasma in acute cerebral hemorrhage with multiple organ dysfunction syndrome caused by systemic inflammatory response syndrome

Objective To investigate the clinical significance of changes in proinflammatory cytokines and coagulation system in the patients with acute cerebral hemorrhage with multiple organ dysfunction syndrome(MODS) caused by systemic inflammatory response syndrome(SIRS).Methods Compared the data from 103 case of patients with acute cerebral hemorrhage with MODS caused by SIRS with those from 30 healthy persons at the first day after admission.The level of antithrombin was measured by photometry immune-turbidimetric test with automated biochemical analysis.While the quantity of tumor necrosis factor-α was measured by enzyme linked immunosorbant assay.Results Antithrombin decreased but tumor necrosis factor-α markedly increased in acute cerebral hemorrhage with MODS caused by SIRS compared with those of healthy persons(P0.05).Conclusion Results suggested that proinflammatory cytokines might have some connection with the coagulation system.They can be regarded as laboratory index for judging the condition and prognosis in patients with cerebral hemorrhage.