Relationship of vascular endothelial dysfunction to the patients with systemic inflammatory response syndrome and multiple organ dysfunction syndrome

Objective To inquire into relationship of vascular endothelial dysfunction to the patients with systemic inflammatory response syndrome(SIRS) and multiple organ dysfunction syndrome(MODS).Methods Plasma levels of tissue plasminogen activator(t-PA),plasminogen-activator inhibitor-1(PAI-1),circulation endothelial cell(CEC) and serum levels of endothelin(ET-1),nitric oxide(NO) were determined in all the patients dynamically and in healthy persons,and at the same time the patients were evaluated with multiple organ dysfunction score.Results Blood levels of ET-1,PAI-1,CEC were significantly high in the SIRS group,MODS group and no-survivor group.Blood levels of NO,t-PA were significantly low in the SIRS group,MODS group and no-survivor group.Multiple organ dysfunction score was high in SIRS group, MODS group and no-survivor group.Conclusions There are endothelial dysfunctions in the patients with SIRS;Measuring CEC and the markers of injured vascular endothelium dynamically may be good way in evaluating the prognosis of patients with SIRS;Multiple organ dysfunction score is sensitive parameters in evaluating the patients with MODS.