Effects of Ranitidine Bismuth Citrate in Helicobacter pylori eradication therapy in patients with peptic ulcer

Objective To explore the effect of Ranitidine Bismuth Citrate in H.pylori eradication in the peptic ulcer population.Methods Sixty-six cases of gastric or duodenal ulcer patients with positive H.pylori received the treatment of Ranitidine Bismuth Citrate capsules(34 cases) or rabeprazole(32 cases),plus the clarithromycin and metronidazole.All patients were subjected to H.pylori eradication therapy for 7 days,followed by the only treatment of Ranitidine Bismuth Citrate capsules(0.4,Bid) or rabeprazole(10 mg,Bid) for another 35 days.Patients were performed dupper endoscopy 6~8 weeks after completion of all the treatment.The rate of ulcer healing and the eradication rate of H.pylori were observed.Results The excellent patients were 20/34(58.8%) and effective patients were 9/34(26.5%),the curerate rate of Ranitidine Bismuth Citrate capsules of the therapy goup was 85.3%;at the same time,excellent patients were 18/32(56.3%) and effective patients were 8/32(25.0%) in control group,and the curerate rate of the control group was 81.3% in control group.There was no significant difference between the two groups(P0.05).Conclusion The 7-days therapy with Bismuth Citrate capsules is worthy of clinical application in curing the H.pylori relative peptic ulcer.