Application research about brain perfusion imaging and head and neck angiography in carotid artery stenosis on 256-slice spiral CT

Objective:To discuss the correlation of carotid artery stenosis and blocking with cerebral perfusion reduction on 256 spiral CT.Methods:76 patients underwent joint inspection of CTA and CTP.We selected the patients with no carotid artery stenosis as control group according to CTA images,the remaining patients were divided into three levels: mild,moderate and severe according to the degree of carotid artery stenosis,and each level was analysed,independently.All patients were selected the interest region to process image measurements of CBV,CBF,MTT,TTP.We contrasted the lesion side and uninjured side of patients with unilateral carotid artery stenosis and contrasted the patients with bilateral carotid artery stenosis by t test.Results:There were 15 cases patients with no carotid artery stenosis,the value of CBV CBF MTT TTP were(watershed area 2.5±0.6;38±12;5.4±0.6;21±6 basal ganglia 5.5±0.4;95±15;3.2±1.1;20 ±5).There were 33 cases with unilateral carotid artery stenosis.Among these,there were 12 cases with mild to moderate stenosis,and no statistically difference of each CBV,CBF,MTT,TTP(P0.05).There were 9 cases with severe stenosis,in watershed area there were high statistically differences of CBF,MTT(P 0.01),statistically difference of TTP(P0.05),no statistically difference of CBV(P0.05).In basal ganglia,there were high statistically difference of MTT(P0.01),statistically difference of CBF(P0.05),no statistically differences of CBV,TTP(P0.05).There were 28 cases patients with bilateral carotid artery stenosis.There were 11 patients with severe stenosis,and statistically difference of CBF,MTT(P0.05).Conclusion:Affected by collateral circulation and other factors,there is correlation of internal severe carotid artery stenosis or occlusion with the blood perfusion reduction,but no apparent correlation of mild to moderate stenosis with cerebral perfusion reduction.