Effects of enteral nutrition and total parenteral nutrition for severe acute pancreatitis patients in early stage

Objective:To compare the effect of enteral nutrition and total parenteral nutrition in severe acute pancreatitis patients in early stage.Method:Thirty-nine severe acute pancreatitis patients admitted in our hospital in the past two years were divided into 3groups,early enteral nutrition group(EN,n=13),total parenteral nutri- tion group(TPN,n=14),and control group(n=12).Based on comprehensive treatment,the patients in group EN were given enteral nutrition by endoscopic nasojejunal feeding,while those in group TPN were given venous sugar amino acid treatment in the early stage,the patients in control group had no nutrition support.The WBC,A- PACHEⅡscore,Ranson score,C-reactive protein(CRP),serum amylase,urinary amylase and serum albumin 1 week,2weeks and 3weeks after treatment were observed.The infection complication incidence,mortality rate and hospital stays were paid attention.Result:Differences of APACHEⅡscore and Ranson score in the three groups of patients had no statistical difference.Two weeks after treatment,the levels of WBC and CRP in EN and TPN groups were significantly lower than the control group.Two weeks and three weeks after treatment,the level of se- rum albumin in EN and TPN groups was obviously higher than control group(P0.05).The infection rate,com- plication incidence,average hospital stays in EN and TPN groups were significantly lower than control group(P 0.05).However,the abdominal distension and gastrointestinal hemorrhage rate of SAP patients,especially the aged in TPN group were significant lower than other groups.Conclusion:Early nutrition support can improve the nutri- tional status of SAP patients,shorten the hospital stays,reduce the infection rate,complication incidence and mor- tality rate.However,different nutrition support methods differ in different patients.