Clinical and pathological analysis on 35 children lupus nephritis

Objective: To explore the clinical features of lupus nephritis(LN) in childhood and their relationship with renal pathological types. Methods: The clinical and laboratory data of 35 cases of lupus nephritis(LN) in childhood(of which,30 have integrated renal pathological data) were retrospectively analyzed. Results: Of the 35 cases of LN, there were 11 males and 24 females, with a ratio of male to female 1 ∶ 2.2, and the mean age of 10.1 years. The incidence rate of female patients between 10 and 14 years was the highest, with a percentage of 42.9%. All patients showed renal lesion, and some of those punctured patients had kidney disease as their initial manifestations (42.8%). In these patients, the incidence rate of nephrotic syndrome was 65.7% and fever 60%, skin lesion 57.1%, arthritis 40%. Laboratory examination, anemia 45.7%, decreased C3 complement 77.1%, ANA 85.7%,anti-dsDNA 51.4%. All the 30 punctured cases showed some abnormality of renal pathology. Class Ⅳ had the largest cases with a percentage of 70%, followed by class Ⅱ(16.7%). Of all cases, 3 cases were repeated renal biopsy, 1 case of class Ⅳ turn to class Ⅲ, 2 case of class Ⅴ turn to class Ⅳ. Conclusion:The clinical features of lupus nephritis in childhood and their relationship with renal pathological types showed their own characteristics. but the pathological class showed little correlation with clinical features. To emphasize the value of renal biopsy of LN in childhood is of great importance.