2009•The Journal of Pharmaceutical PracticeRequires access

Studies on the chemical constituents of Rosa laevigata Michx fruits

Hou‐Wen Lin

Abstract

Objective:To investigate the chemical constituents from fruits of Rosa laevigata Michx fruits.Methods:Multi-chromatographic methods including Silica gel column chromatography and Sephadex LH-20 gel permeation were employed for the isolation and purification.The structures were identified on the basis of chemical evidence and spectral data.Results:Five compounds were isolated and identified as:2α,3β,19α-trihydroxyolean-12-en-28-oic acid(Ⅰ),kaempferol(Ⅱ),potengriffioside A(Ⅲ),β-sitosterol(Ⅳ),daucosterol(Ⅴ).Conclusions:Compound Ⅰ was isolated from fruits of Rosa laevigata Michx for the first time.

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Key concepts: Daucosterol, Sephadex, Silica gel, Chemistry, Chromatography, Kaempferol, Chemical constituents, Column chromatography