Expression of prostatic specific membrane antigen and prostatic specific antigen in prostatic adenocarcinoma tissue

Objective To observe and compare the expression difference of prostatic specific membrane antigen (PSMA) and prostatic specific antigen (PSA) in different prostatic tissues and compare the roles of PSMA and PSA in the diagnosis of prostate adenocarcinoma.Methods Seventy cases of prostate adenocarcinoma,21 cases of prostatic intraepithelial neoplasms and 20 cases of benign prostatic hyperplasia were analyzed for the expression of PSMA and PSA with PSMA monoclonal antibody and PSA monoclonal antibody by using ABC immunohistochemical staining.Results High expression of PSMA was detected in prostatic adenocarcinoma tissues,while high expression of PSA was detected in benign prostatic hyperplasia;Positive ratio of PSMA expression was obviously higher than that of PSA in prostatic adenocarinoma.Conclusion PSMA may be a more specific marker for prostatic tumor than PSA and could substituted for PSA as a novel marker for the diagnosis of prostatic adenocarcinoma.