Clinical study on the relationship between the changes of plasma level of brain natriuretic peptide and prognosis of patients with sepsis

Objective: To explore the guidance value of the changes of plasma level of brain natriuretic peptide (BNP) during treatment of patients with sepsis and its effect on prognosis. Methods: One hundred and two cases with sepsis were divided into sepsis group (35 cases), severe sepsis group (37 cases) and septic shock group (30 cases), 40 healthy persons were selected as the control group. All the patients were also divided into survivor and death group according to whether they survived within 2 weeks. Plasma level of BNP, left ventricular ejection fraction (LVEF) and APACHE II score were compared. Results: Plasma level of BNP on 1st and 3rd day after admission in the three sepsis groups were significantly higher than that in the control group, and with the progression of the severity of the disease, plasma level of BNP was increased (P0.05). There was no significant relation between plasma level of BNP and APACHE II score on 1st and 3rd day after admission in sepsis group (P0.05), while positive relation was found in both severe sepsis and septic shock group (P0.05). Compared with those of survivor group, plasma level of BNP on 1st and 3rd day after admission in death groups increased, and LVEF decreased significantly (P0.05). By Logistic regression analysis, increased plasma level of BNP and decreased LVEF were all independent predictors of mortality of sepsis. Conclusions: Plasma level of BNP increased significantly in patients with sepsis, and it can be used as an indicator for severity of the disease and prognosis in patients with sepsis.