Plasma brain natriuretic peptide (BNP) levels in patients with sepsis and analysis of brain natriuretic peptide on early prognosis

Objective To investigate plasma brain natriuretic peptide( BNP) levels in patients with sepsis and analysis of brain natriuretic peptide on early prognosis. Methods Randomly selected from January 2011 to July 2013 in our hospital ICU ward with135 cases of sepsis patients were divided into group of 50 cases of sepsis group,46 cases of severe sepsis group,39 cases of septic shock group,and selected 50 cases in the corresponding period Outpatient as the control group. We detected brain natriuretic peptide,echocardiography,blood lactate and other tests in the first day,and APACHE Ⅱ score evaluated at 4 weeks. Analysis of plasma BNP levels in patients,lactic acid,left ventricular ejection fraction( LVEF) and APACHE Ⅱ score changes,and subgroup analysis were performed. Results ①Brain natriuretic peptide levels in each group compared with significant difference the control group( P 0. 05),brain natriuretic peptide levels,APACHE Ⅱ score in septic shock group were higher than the severe sepsis group and sepsis group,severe sepsis group was significant difference compared with sepsis group( P 0. 05); LVEF of septic shock group compared with severe sepsis and septic group was lower,and lactate levels was higher than the other two group( P 0. 05),but LVEF,lactate levels in severe sepsis group and sepsis group was no significant difference( P 0. 05). ②Brain natriuretic peptide was positively correlated with LVEF,lactic acid and APACHE Ⅱ was negatively in septic shock group with pearson correlation analysis( P 0. 05); brain natriuretic peptide of severe sepsis group were correlated with LVEF,and negatively correlated with APACHE Ⅱ( P 0. 05); brain natriuretic peptide of sepsis group and APACHE Ⅱwere negative correlation( P 0. 05). ③Four weeks of mortality in patients with septic shock group were highest( P 0. 05),severe sepsis and sepsis group compared with no significant difference( P 0. 05). Subgroup analysis showed that BNP,LVEF,APACHE Ⅱ score,lactic acid of the death group were higher than the survival group( P 0. 05),but after multivariate Logistic regression analysis showed elevated BNP levels,higher APACHE Ⅱ score,increased lactic acid levels were independent risk factors in death( OR = 1. 210,1. 107,1. 098,P 0. 05). Conclusion Plasma BNP levels in patients with sepsis was significantly higher,and with the left ventricular systolic function,early prognosis,BNP levels could be used as the detection of disease severity in patients with sepsis and evaluated early prognosis.