Expressions of estrogen receptor,progesterone receptor and human epithelial receptor-2 in elderly breast cancer patients and their clinical significance

Objective:To analyze the expressions of estrogen receptor(ER),progesterone receptor(PR) and human epithelial receptor-2(CerbB2) in elderly patients with breast cancer,and to investigate its clinical significance.Methods:One hundred and twenty-five female breast cancer patients aged 65years and older were enrolled in the study.Clinical data of all the patients were retrospectively reviewed.Expressions of ER,PR and CerbB2 were detected by immunohistochemistry.Correlation between expressions of ER,PR and CerbB2 and tumor size,histological grade,tumor location,lymph node metastasis were statistically analyzed.Results:The positive expressions of ER,PR and CerbB2 were 84(67.2%),83(66.4%) and 25(20.0%),respectively.The expressions of ER and PR were correlated with histological grade,while CerbB2 expression was correlated with histological grade,tumor size and lymph node metastasis,respectively(both P 0.01).Three and five years overall survivals of elder patients were 74.9%and 62.0%;the mean overall survival was 6.9 years.Conclusions:The increased expressions of ER,PR and decreased expression of CerbB2 in female breast cancer patients reflected the pathobiological features of the cancer,which would be helpful for the treatment and surgical operation of breast neoplasms.