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2011•Zhongguo shiyan fangjixue zazhiRequires access

Protective Effects of Chlorogenic Acid on Liver Injury in Mice

Gao Yin-hui

Open publisher page 3 citations

Abstract

Objective:To observe the protect effects of chlorogenic acid on liver-injury of mice induced by Carbon Tetrachlotide(CCl4).Methods:Animals were devided into 6 groups:normal group,model group,solvent group,the chlorogenic acid high-dose group,middle-dose group,low-dose group.The dose of chlorogenic acid is ig 14,7,3.5 g·kg-1respectively.The mice models of acute chemical liver injury was induced by CCl4.The indexes of the live and spleen,alanine transaminase(ALT) and aspartate transaminase(AST) activity in serum were examined.Superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)activity,MDA level in liver tissue were determined by immunological liver injury.Meanwhile liver pathological examination was observed by light microscope.Result: The chlorogenic acid(14,7,3.5mg·kg-1)could remarkablly resist the increase of ALT(40.01±7.14),(51.19±9.45),(62.66±9.01)U·L-1,AST(43.59±4.32),(52.99±5.97),(66.97±7.34)U·L-1,decreased the MDA level(21.68±10.28),(28.54±6.84),(35.51±9.87) nmol·g-1,and could improve SOD activity(112.98±8.41),(98.36±11.18),(81.76±9.88) U·g-1and GSH-Px level(196.19±10.56),(169.77±13.61),(141.57±15.11) U·g-1(P0.01 versus model group for above results).Conclusion:Chlorogenic acid has remarkable protective effects on liver –injury in mice.

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What this paper is about

Objective:To observe the protect effects of chlorogenic acid on liver-injury of mice induced by Carbon Tetrachlotide(CCl4).Methods:Animals were devided into 6 groups:normal group,model group,solvent group,the chlorogenic acid high-dose group,middle-dose group,low-dose group.The dose of chlorogenic acid is ig 14,7,3.5 g·kg-1respectively.The mice models of acute chemical liver injury was induced by CCl4.The indexes of the live and spleen,alanine transaminase(ALT) and aspartate transaminase(AST) activity in serum were examined.Superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)activity,MDA level in liver tissue were determined by immunological liver injury.Meanwhile liver pathological examination was observed by light microscope.Result: The chlorogenic acid(14,7,3.5mg·kg-1)could remarkablly resist the increase of ALT(40.01±7.14),(51.19±9.45),(62.66±9.01)U·L-1,AST(43.59±4.32),(52.99±5.97),(66.97±7.34)U·L-1,decreased the MDA level(21.68±10.28),(28.54±6.84),(35.51±9.87) nmol·g-1,and could improve SOD activity(112.98±8.41),(98.36±11.18),(81.76±9.88) U·g-1and GSH-Px level(196.19±10.56),(169.77±13.61),(141.57±15.11) U·g-1(P0.01 versus model group for above results).Conclusion:Chlorogenic acid has remarkable protective effects on liver –injury in mice.

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Available abstract

Objective:To observe the protect effects of chlorogenic acid on liver-injury of mice induced by Carbon Tetrachlotide(CCl4).Methods:Animals were devided into 6 groups:normal group,model group,solvent group,the chlorogenic acid high-dose group,middle-dose group,low-dose group.The dose of chlorogenic acid is ig 14,7,3.5 g·kg-1respectively.The mice models of acute chemical liver injury was induced by CCl4.The indexes of the live and spleen,alanine transaminase(ALT) and aspartate transaminase(AST) activity in serum were examined.Superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)activity,MDA level in liver tissue were determined by immunological liver injury.Meanwhile liver pathological examination was observed by light microscope.Result: The chlorogenic acid(14,7,3.5mg·kg-1)could remarkablly resist the increase of ALT(40.01±7.14),(51.19±9.45),(62.66±9.01)U·L-1,AST(43.59±4.32),(52.99±5.97),(66.97±7.34)U·L-1,decreased the MDA level(21.68±10.28),(28.54±6.84),(35.51±9.87) nmol·g-1,and could improve SOD activity(112.98±8.41),(98.36±11.18),(81.76±9.88) U·g-1and GSH-Px level(196.19±10.56),(169.77±13.61),(141.57±15.11) U·g-1(P0.01 versus model group for above results).Conclusion:Chlorogenic acid has remarkable protective effects on liver –injury in mice.

Key concepts: Chlorogenic acid, Aspartate transaminase, Liver injury, Superoxide dismutase, Glutathione peroxidase, Glutathione, Alanine transaminase, Transaminase

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