Clinic value of Assay of serum cholinesterase and albumin in Child-pugh classification in patients with cirrhosis

Objective To determine serum cholinesterase(ChE) and albumin(Alb) in patients with cirrhosis and investigate the relationship of ChE and Alb level with Child-pugh classification.Methods With the help of HATACHI-7600 analyzer,serum cholinesterase was assayed by colorimetry and serum albumin was determined by bromocresol green method.Results The patients with cirrhosis were divided into the levels(A,B,C level) according to Child-pugh classification.Serum ChE activity declined significantly in all patients with cirrhosis compared to healthy subjects; and significant differences existed in ChE activity in all levels(P0.01).There was positive correlation between ChE activity and Alb concentration(r=0.56).Conclusion Serum ChE activity and Alb concentration could be used as effective markers for not only judging liver cells injury but also evaluating the diagnosis and prognosis in patients with cirrhosis.It was helpful to child-pugh classification.