The Practical Value of Cholinesterase in Evaluating Liver Reserve Function of Cirrhosis Patients Due to Hepatitis Virus B

Objective: To observe the practicing value of cholinesterase in evaluating liver reserve function of cirrhosis patients due to hepatitis virus B.Methods: 501 cirrhosis patients due to hepatitis virus B were divide into three groups according to Child score.Serum cholinesterase of the patients were detected with enzyme rate method;Meanwhile,serum albumin was detected with Bromcresol green test and serum plasma prothrombin time was detected with clotting assay.Using analysis of variance(ANOV),the practicing value of cholinesterase were analyed in evaluating liver reserve function of cirrhosis patients in defferent Child grades.Using analysis of correlation,the correction bewteen cholinesterase and albumin and serum plasma prothrombin time were analyed.Results: The patients of cirrhosis were strictly into A,B and C grades according to the modified Child score.The results showed that cholinesterase trended to significantly decrease in the three grades Child A(5469.04±1777.31 U/L),Child B(2935.08±1206.95 U/L) and Child C(1810.40±724.72 U/L)(F=261.114,P=0.000.Basicly in the patients of cirrhosis,cholinesterase was positively correlated with albumin,and negatively correlated with serum plasma prothrombin time.In Child A grade,cholinesterase was also positively correlated with albumin and negatively correlated with serum plasma prothrombin time.In Child B grade,cholinesterase was still negatively correlated with serum plasma prothrombin time,but there was no significant correlation bewteen it and albumin.In Child C grade,cholinesterase positively correlated with albumin,but there was no significant correlation bewteen it and serum plasma prothrombin time.Conclusion: Related with the damage severity of liver cells,cholinesterase can response to the liver reserve function.