Effects of thrombolytic therapy on blood vessel reperfusion in different phases after acute myocardial infarction in elderly patients

Objective:To study the effect of thrombolytic therapy on blood vessel reperfusion in different times after acute myocardial infarction (AMI).Method:One hundred and sixty nine elderly patients with AMI were divided into five groups according to different times after intravenous thrombolytic therapy.The groups were≤2 h,2~4 h,4~6 h,6~12 h and 12~24 h.Result:Reperfusion rate of the 5 groups were 80.8 %, 75.6 %, 71.0 %, 47.6 % and 46.2 % respectively,with significant difference between the former three groups and the latter two groups (P 0.05 ).The mortality rate were 0, 2.5 %, 9.6 %, 14.3 % and 15.4 % respectively.The time from the begining of bolt dissolving to blood vessel reperfusion was positively related with the time from onset of AMI to thrombolytic therapy (P 0.05 ).Only ( 58.3 ±24) minutes were needed in the cases within 2 hours after onset of AMI,but (126± 30.3 ) minutes in the cases within 6~12 h.Conclusion:In the elderly patients (over 70 years old),within 6 after onset of AMI,the reperfusion effect of blood vessels was the best.As for the cases within 6~12 h after the onset of AMI,the thrombolytic effect were also favourable.