Clinial significance of serum total bile acid detection in liver diseases

Objective To investigate the clinical value of serum total bile acid(TBA) in different types of hepatic diseases including acute viral hepatitis,chronic virus hepatitis,fulminant hepatitis and liver cirrhosis.Methods 82 healthy controls, 45 cases of acute viral hepatitis, 156 cases of chronic virus hepatitis B, 41 cases of fulminant hepatitis and 104 cases of cirrhosis cases were enrolled in our study. The venous blood were collected and serum TBA was detected with automated biochemistry analysis system.Results Serum TBA in acute viral hepatitis group, chronic virus hepatitis B group, fulminant hepatitis group and cirrhosis group was 42, 15, 66 and 9 times the value of healthy control group respectively. Serum TBA in chronic virus hepatitis B group increased with state of the illness.Conclusion Detection of serum TBA is helpful for assessment of liver function and diagnosis of viral hepatitis and cirrhosis.