Expression of YKL-40 and survivin in prostate carcinoma as related to prognosis

Objective To explore the correlation between expression of YKL-40 and Survivin and the clinico-pathology in prostate carcinoma,and to evaluate the value of these two aspects in prognosis estimation.Methods The expression of YKL-40 and Survivin was detected immunohistochemically in 56 cases of prostate carcinoma.Kaplan-Meier and multivariate Cox proportional hazards regression model analysis were applied to compare the survival curves and screen the independent prognosis factors respectively.Results Of 56 cases of prostate carcinoma,YKL-40 and survivin were expressed in 73% and 80%,respectively,positively correlated with each other,and were associated with Gleason's score and bone metastasis(P0.05).Thirty-four cases(61%)were found to be double-positive for YKL-40 and Survivin expressions.Patients with positive expression of YKL-40 and/or Survivin and high Gleason's score expe-rienced significantly shorter length of survival.Cox regression indicated that YKL-40 and Gleason grade were inde-pendent prognostic factors for survival in prostate carcinoma.Conclusion The expression of YKL-40 and Survivin was found to be frequently elevated in prostate carcinoma,and were linked to Gleason's score,clinical stage,bone metastasis and postoperative survival.The biomarkers may be useful to evaluate the degree of malignancy and to moni-tor the prognosis of prostate carcinoma.