The double intervention clinical application reseach of TACE with PAI on massive hepatocellular carcinoma

Objective:To study the efficacy of TACE combined with PAI(percutaneous acetic acid injection) on MHCC(massive hepatocellular carcinoma).Methods:TACE was performed in 57 patients with MHCC,which were randomly divided into group A(n=28) and group B(n=29),patients in group A received conventional TACE for the first time and then received low dose TACE(10mg mitomycin C) for the repeated treatment,re-examined CT scans after TACE for a week,based on filled status of lipiodol in the lesions,PAI was underwent in the area of rarefaction or defect filled by Lipiodol.Patients in the group B received conventional TACE.Then the survival rate and masses variation and hepatic function and a-FP and side effects were observed.Results:The survival rate at 1st,2nd and 3rd year after TACE were 96.4%,78.6% and 32.1% for A group,and 65.5%,48.3% and 20.7% for B group.Diminished masses were found in all patients in A group,But in B group,diminished masses were found in 20 cases,unchanged in 5 cases and enlarged in 4 cases.Conclusion:The efficacy of TACE combined with PAI are significantly better than that of TACE only,low doses TACE produces less hepatic damage and less side effects.