Effects of valsartan and enalapril on patients with essential hypertension

Objective To compare the therapeutic effect and safety of valsartan with that of enalapril on patients with essential hypertension.Methods The patients were randomized to two groups:Valsartan group(n=51),Enalapril group(n=49).The effective rate was observed at 4th and 8th week.Results The blood pressure(BP) decreased significantly in both 2 groups after 2,4 and 8 weeks,and BP decreased smoothly and continuously during the entire treatment period.The effective rate for decreased DBP treatment were 88.2% and 92.2% respectively in Valsartan group after 4 and 8 weeks,and that of Enalapril group were 81.6% and 87.8% respectively.There was no significant difference between 2 groups(P0.05).Conclusion Valsartan is a safe,effective,tolerable antihypertensive drug.