Clinical observation of infertility patients for two ovulation induction in women with polycystic ovarian syndrome

Objective: To search for a new drug for ovulation induction through a comparison of the effects and pregnancy outcome of two ovulation induction in women with polycystic ovarian syndrome (PCOS). Methods: 86 cases of patients with PCOS undergoing ovarian stimulation were randomly divided into Letrozole (LE) group (40 cases) and Clomiphene Critate (CC) group (46 cases). Subjects in LE group received LE with a dosage of 5 mg/d from the 3rd day to the 7th day of menstruation, and received HMG injection from the 7th day to HCG day. Subjects in CC group received CC with a dosage of 100 mg/d from the 5th day to the 9th day, and received HMG injection from the 6th day to HCG day. The number of follicle ≥14 mm and follicle ≥16 mm, endometrial thickness and pattern were observed on HCG day. Meanwhile, pregnancy rate, case of miscarriage, ectopic and ovarian hyperstimulation syndrome (OHSS) were recorded. Results: Endometrial thickness and endometrial pattern on HCG day in LE group were thicker than CC group (P0.01). The number of follicle ≥14 mm in LE group on HCG day was significantly decreased, and it showed a statistical difference compared with CC group (P0.01). No patient occurred OHSS. The pregnancy rate and ongoing pregnancy rate of LE group were higher than those of CC group, but they showed no statistical difference. Conclusion: LE has a similar ovulation induction effect and pregnancy rate as CC.