Study on the Correlation Between Interleukin(IL)-18 gene Promoter-607 A/C Polymorphism and Risk of CHD

Objective To investigate the correlation between interleukin(IL)-18 gene promoter-607 A/C polymorphism and the risk of CHD in Chinese Han population.Methods The single nucleotide polymorphism at the position of interleukin(IL)-18 gene promoter-607 A/C were detected by sequence specific primer-polymerase chain reaction(SSP-PCR) in 141 patients with CHD and 240 healthy controls.The genotype and allele frequencies were analyzed in both CHD group and control group.Meanwhile,the blood lipids were measured by enzyme method.Results In CHD group and control group,the CC,CA,AA genotype frequencies of IL-18 gene promoter-607C/A were 33.3%,50.4%,16.3% and 21.3%,51.3%,27.4%,respectively;the C,A allele frequencies were 58.5%,41.5% and 46.9%,53.1%,respectively.The frequency of genotype CC and allele C at position-607 C/A of CHD group were significantly higher than those of control group(χ2=4.56,P=0.03 and χ2=7.49,P=0.01,respectively).Conclusion The CC genotype of IL-18 gene promoter-607 C/A polymorphism may contribute to the susceptibility of CHD in Chinese Han population,and allele C may be a genetic risk factor of CHD.