Association of interleukin-18 gene 105A/C genetic polymorphism with susceptibility to coronary heart disease

Objective:To investigate the association of interleukin-18 gene 105 genetic polymorphism in the coding region with susceptibility to coronary heart disease (CHD).Methods:IL-18 gene 105 genotypes in 162 CHD patients and 134 controls were detected using PCR-restriction fragment length polymorphism(RFLP) assay,and the association of genetic polymorphism with susceptibility to CHD was analyzed. Results:The frequencies of A/A,A/C,C/C types of interleukin-18 gene 105 polymorphism in CHD patients and controls were 70.4%,29.0% and 0.6%vs 88.1%,11.9% and 0%. Compared with AA genotype,the relative risk for CHD in people with AC genotype was 3.041(95% confidence interval [CI] 1.631-5.669). The relative risk for CHD in people with C allele was 2.806 higher than people with A allele(95%CI 1.556-5.061)(P0.01). Conclusions:IL-18 gene 105 genetic polymorphism is associated with CHD in Han nationality of Fujian province,people with AC or CC genotypes take higher risk of suffering from CHD.