Study on expressions of Decorin mRNA、 p57~(KIP2) mRNA and TGF-β1 and their clinical significance in lung cancer

Objective To investigate the expressions of Decorin mRNA、p57KIP2 mRNA and TGF-β1 and to analyze their relationships with pathogenesis and clinical characteristics in lung cancer.Methods The expressions of Decorin mRNA and p57KIP2 mRNA of 64 cases of lung cancer and 12 cases of normal lung tissues adjacent to tumor tissues were examined by in situ hybridization.and expression of TGF-β1 of 64 cases of lung cancer and 12 cases of normal lung tissues were examined by immunohistochemistry(streptavidin-perosidase).Results The normal tissues showed a higher expre-ssion of Decorin mRNA(66.7%,8/12) than the tumor tissues(15.6%,10/64)(P0.05).The expression rate of p57KIP2 mRNA in squamous cell carcinoma of the lung(LSCC) was 68.4%(13/19),being higher than adenocarcinoma of the lung(LAC),large cell lung adenocarcinoma(LCLC),small cell lung adenocarcinoma(SCLS)and alveolar carcinoma(P0.05).The expression rate of TGF-β1 in SCLS was lower than LAC,LCLC,LSCC and alveolar carcinoma.In lung cancer without lymph node metastasis,the expression of Decorin mRNA and p57KIP2 mRNA increased significantly(P0.05).Conclusions These results suggest that Decorin gene,p57KIP2 gene and TGF-β1 are closely related to the lung cancer metastasis and histological classification.