The Effects of Telmisartan to The C-reactive Protein and Microalbuminuria Levels in Obesity Associated Hypertension People

Objective To explore the effects of telmisartan to the C-reactive protein(CRP) and the microalbuminuria(MAU) of obesity associated hypertension patients.Methods One hundred mild and moderate hypertension and obesity people were divided into two groups by random-number table method,the amlodipine(control) group and the telmisartan(observation) group,50 patients in each group.All the patients were visited every 2 weeks,altogether for 24 weeks.And before and after treatment,the blood pressure,waist circumference(WC) and body mass index(BMI),CRP and MAU were measured.Results 24 weeks after treatment,①SBP in the observation group was(130 ± 8) mmHg vs in the control group(135 ± 9) mm Hg,DBP in the observation group was(82 ± 6) vs control control(85 ± 6) mm Hg,the differences were statistically significant(P 0.05).②WC in the observation group was(93.2 ± 3.8) cm vs in the control group(94.7 ± 3.6) cm;BMI in the observation group was(29.8 ± 3.2) kg / m2 vs in the control group(31.4 ± 3.1) kg / m2,Both the comparison of the observation group before and after treatment,and the comparison between two groups after treatment were statistically significant(P 0.05).③CRP in the observation group decreased to(17.52 ±6.48) ng/L vs in the control group decreased to(20.47 ± 7.08) ng/L,MAU in the observation group decreased to(20.86 ± 13.87) mg / L vs in the control group decreased to(20.86 ± 13.87) mg / L,Both the comparison of the observation group before and after treatment,and comparison between the two groups after treatment were statistically significant(P 0.05).Conclusion Telmisartan is more effective than amlodipine in controlling the blood pressure,lowering the obesity related indexes,and decreasing the CRP and MAU level in treating obesity associated hypertension,which is worth clinical application.