THE EFFECT OF IRBESARTAN ON HYPERSENSITIVITY PROTEIN BRAIN NATRIURETIC PEPTIDE OF PATIENTS WITH HYPERTENSION AND HEART FAILURE

Objective To study the Irbesartan in treatment of hypertension with heart failure of hypersensitivity protein( hs- CRP) and the effect of brain natriuretic peptide( BNP). Methods 124 patients in our hospital were randomly divided into observation group and control group with draw methods,62 cases of each group. The two groups were accepted blood pressure and other conventional treatment; the observation group at the same time with irbesartan treatment. Two groups of clinical curative effect,the BNP,hs- CRP,various index signs and the ultrasonic cardiogram test Results were compared. Result 1 two groups total effective93. 55% VS 80. 65%,the observation group was significantly higher( p 0. 05); 2 the observation group after treatment the BNP,hs- CRP levels( 104. 62 ± 22. 84) mg / L、( 4. 68 ± 1. 51) mg / L was significantly lower( p 0. 05),compared with the control group( 189. 50 ± 29. 67) mg/L、( 7. 66 ± 1. 72) mg/L; 3 Observation group after treatment LVDd,LVSd respectively( 54. 61 ± 4. 28),( 40. 62 ± 6. 17) was significantly lower than the control group( 62. 61 ± 6. 33),( 53. 10 ± 7. 31),and LVEF,FS respectively( 49. 27 ±7. 44),( 42. 30 ± 7. 18) was significantly higher than control group( 42. 30 ±7. 18),( 16. 87 ±5. 06)( p 0. 05); 4 The incidence of adverse effects in two groups had no significant difference( p 0. 05). Conclusion Irbesartan in treatment of hypertension with heart failure can significantly reduce the BNP and hs- CRP levels,improve heart function,and has high clinical value.