ScholarLens Back to search
2001•Zhongguo yaofangRequires access

Studies on Pharmacokinetics and Relative Bioavailability of Two Kinds of Cefaclor Capsule in Healthy Volunteers

Dong Won Chun

Open publisher page 0 citations

Abstract

OBJECTIVE:To study the pharmacokinetics and relative bioavailability of two kinds of cefaclor capsule in healthy volunteersMETHODS:Plasma cefaclor concentrations were measured with HPLC methodEach subject was administered with a single oral dose of domestic or imported cefaclor capsule(500mg)in a randomized crossover studyRESULTS:Plasma concentration-time curves of domestic and imported cefaclor capsules fitted to a one-compartment open model with a first order absorptionThe peak plasma levels(Cmax)averaged(1324±242)and (1329±314)μg/ml,times to reach the peak level(Tmax)were (058±0192)and(055±010)h,the elimination half lives(T1/2)were (042±009)and(041±009)h,the areas under the plasma concentration-time curve(AUC0～T)were (1581±153)and(1568±197)h/(μg·ml)respectivelyCONCLUSION:The results of statistical analysis showed that the two formulations were bioequivalentThe relative bioavailability of domestic capsule was(10084±778)%

About this research paper

What this paper is about

OBJECTIVE:To study the pharmacokinetics and relative bioavailability of two kinds of cefaclor capsule in healthy volunteersMETHODS:Plasma cefaclor concentrations were measured with HPLC methodEach subject was administered with a single oral dose of domestic or imported cefaclor capsule(500mg)in a randomized crossover studyRESULTS:Plasma concentration-time curves of domestic and imported cefaclor capsules fitted to a one-compartment open model with a first order absorptionThe peak plasma levels(Cmax)averaged(1324±242)and (1329±314)μg/ml,times to reach the peak level(Tmax)were (058±0192)and(055±010)h,the elimination half lives(T1/2)were (042±009)and(041±009)h,the areas under the plasma concentration-time curve(AUC0～T)were (1581±153)and(1568±197)h/(μg·ml)respectivelyCONCLUSION:The results of statistical analysis showed that the two formulations were bioequivalentThe relative bioavailability of domestic capsule was(10084±778)%

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

OBJECTIVE:To study the pharmacokinetics and relative bioavailability of two kinds of cefaclor capsule in healthy volunteersMETHODS:Plasma cefaclor concentrations were measured with HPLC methodEach subject was administered with a single oral dose of domestic or imported cefaclor capsule(500mg)in a randomized crossover studyRESULTS:Plasma concentration-time curves of domestic and imported cefaclor capsules fitted to a one-compartment open model with a first order absorptionThe peak plasma levels(Cmax)averaged(1324±242)and (1329±314)μg/ml,times to reach the peak level(Tmax)were (058±0192)and(055±010)h,the elimination half lives(T1/2)were (042±009)and(041±009)h,the areas under the plasma concentration-time curve(AUC0～T)were (1581±153)and(1568±197)h/(μg·ml)respectivelyCONCLUSION:The results of statistical analysis showed that the two formulations were bioequivalentThe relative bioavailability of domestic capsule was(10084±778)%

Key concepts: Cefaclor, Bioavailability, Capsule, Pharmacokinetics, Cmax, Crossover study, Chemistry, Plasma concentration

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Studies on Pharmacokinetics and Relative Bioavailability of Two Kinds of Cefaclor Capsule in Healthy Volunteers — Research Paper | ScholarLens