Pharmacokinetics and bioavailability of domestic cefaclor

Objective:To determine the pharmacokinetics and relative availability of domestic cefaclor. Methods:The crossover study was conducted in 8 healthy, fast volunteers. They were treated randomly with domestic or imported cefaclor 1 000 mg and their serum and urine drug levels were measured by bioassay. RESULTS: The concentration time curves fitted to a two compartment model. The pharmacokinetic parameters of domestic cefaclor were: mean C max =(20.51±3.84) mg/L, T max =(0.84±0.13)h, t 1/2 β=(1.07±0.38)h, AUC=(27.27±2.88) mg·h/L. The cumulative excretion rate in urine within 24 h was (69.15±6.66)%. The relative bioavailability of domestic cefaclor was 108.43%. CONCLUSION: The domestic and the imported cefaclor are bioequivalent with similar bioavilability.