The correlation of ambulatory pulse pressure and blood lipid with left ventricular hypertrophy in very elderly patients with hypertension

Objective To study correlation of ambulatory pulse pressure(APP) and blood lipid with left ventricular hypertrophy(LVH) in very elderly patients with hypertension.Methods 110 patients of≥80 years old with hypertension were enrolled in this study,and underwent 24 h ambulatory blood pressure monitoring,echocardiographic and lipid examinations.They were divided into two groups according to their APP(≥60 mm Hg,n = 74 and60 mm Hg,n = 36),and were divided into LVH group(n= 50) and non-LVH group(n = 60) according to left ventricular mass index(LVMI).Results Compared with APP60 mm Hg group,LVMI,the incidence of LVH and all SBP parameters increased significantly(P0.05) in APP≥60 mm Hg group.24 h SBP, day SBP,APP and PPI were significantly higher in LVH group than in non-LVH group,while there was no obvious difference in all DBP parameters between the 2 groups.LVMI was positively correlated with APP,PPI,24 h SBP,day SBP and night SBP respectively,whereas negatively correlated with HDL-C significantly.There was no correlation between LVMI and all DBP parameters. Taking LVH as the dependent variable,and APP,PPI,24 h SBP,dSBP,nSBP and HDL-C as the independent variables,only APP was involved in the regression equation(OR = 1.057, 95%CI:1.018—1.096,P = 0.003).Conclusion APP was closely correlated with LVMI and was independent risk factor for LVH in very elderly patients.HDL-C was closely correlated with LVMI.