An investigation on the lymph node metastasis in gastric carcinoma

Objective To investigate the lymph node metastases in gastric carcinoma and its clinical significance Methods The clinicopathological data of 608 patients with gastric carcinoma were analyzed retrospectively The total metastatic rate was calculated Binary logistic regression analysis was used to analyze the influence index of ten clinicopathological factors on the No 7～9 lymph node metastases Results The metastases rate (44 4%) of No 3 group lymph node was the highest seconded by No 15 group (43 2%) The overall lymph node metastases in No 7～9 group was 37 5% The depth of tumor invasion and the lymph node metastases in No 1～6 group were significantly correlated with lymph node metastases in the No 7～9 group ( P 0 05) When lymph node metastasis is diagnosed in No 7～9 by biopsy during operation, the incidence rate of lymph nodes metastasis in No 1～6 is 82 2% with a false positive rate of 15% ( χ 2=18 6, P = 0 000?1 ) While none lymph node metastasis in No 7～9 by biopsy during operation , the incidence rate of none lymph nodes metastasis in No 10～16 is 59 3% with an false positive rate of 12 7% ( χ 2=25 9, P =0 000?1). Conclusions The status of lymph node in No 7～9 groups acts as a sentinel indicating the necessity of further lymph node dissection No 15 group lymphadenectomy should be performed in cases of lower gastric carcinoma when No 7～9 group lymph node metastasis is identified