Observation of the clinical effects of propofol in combination with fentanyl anesthesia for abortion

AIM A comparison of the clinical effects between propofol with fentanyl and propofol for abortion. METHODS Sixty ASA Ⅰ～Ⅱ patients scheduled for abortion under going general anesthesia were enrolled in this study. Age ranged from 20 to 41 years old. They were randomly divided into two groups with 30 cases in each, which are group A: propofol with fentanyl intravenous anesthesia and group B: propofol anesthesia. The anesthesia was induced by either propofol with a dose of 1 μg·kg -1 fentanyl in group A or propofol in group B. The anesthesia was maintained by a continuous propofol infusion. The ECG, SBP, DBP, SPO 2 and BIS were monitored peri operatively. RESULTS (1)At the same depth of anesthesia, the dose of induction and the rate of intravenous infusion in group A were much lower than those of group B. The time to awaking in group A was more rapid than that of group B. (2) There were no significant changes in HR, SBP, DBP and SPO 2 in group A during and after operation ( P 0 05). However, there were significant changes in HR, SBP, DBP from the beginning of induction to during anesthesia ( P 0 05) and the end of operation ( P 0 01) in group B. There was a significant decrease in SPO 2 from the beginning of iduction to during anesthesia ( P 0 01) and the end of the operation ( P 0 05). (3) Percentage of intra operative awareness or recall was 0 in two groups. There were 16 7% patients who felt pain on injection and there were 6 7% patients who felt pain in the low abdominal in group B. Percentage of satisfaction was 100% in each of two groups. CONCLUSION Propofol in combination with fentanyl anesthesia has a much low dose of induction and maintenance of propofol, intra operative hemodynamic stability, a more rapid emergence from anesthesia, and a much low incidence of side efforts, which compare with propofol anesthesia. It is ideal anesthesia for abortion.