Significance of Serum Cardiac Troponin I and Creatine Phosphokinase-Isoenzyme-MB in Asphyxia Neonate

Objective To explore the value of cardiac troponin I (cTnI) and creatine phosphokinase-isoenzyme-MB (CK-MB) on early diagnosis of heart damage in asphyxia neonate.Methods A total of 47 cases of asphyxia neonates were divided into mild-asphyxia group( n=29 ) and severe-asphyxia group(n=18),and the levels of cTnI and CK-MB were quantitatively determinated by ELISA and enzyme kinetics, respectively.Results After birth for the first day, the serum levels of cTnI and enzymatic activities of CK-MB were all significantly higher in mild-asphyxia group[(2.25±0.54)μg/L,(223.4±23.5)U/L]and severe-asphyxia group[(4.25±0.83)μg/L,(256.3±21.8) U/L)]than those in control group(P_a0.01),and the results in severe-asphyxia group were significantly higher than those in mild-asphyxia group(P_a0.01). On the 7 th day after treatment,the serum levels of cTnI and enzymatic activities of CK-MB were no significant differences between the mild-asphyxia group[(0.69±0.18)μg/L,(151.4±18.4)U/L] and control group(P_a0.05), however the results in severe-asphyxia group[(1.54±0.72)μg/L,(188.9±21.5)U/L]were significantly higher than those in control group (P_a0.01).Conclusion High levels of cTnI and CK-MB have been confirmed,and may be used for early diagnosis of myocardial injury in asphyxia neonate.