Detection and clinical analysis of serum cardiac troponin-I and creatine kinase MB isoenzyme in 83 neonates with asphyxia

Objective To investigate the changes of cardiac troponin I(cTnI),creatine kinase MB isoenzyme(CK-MB) and their clinical significance in neonatal asphyxia.Methods 83 neonates with asphyxia(48 cases of mild asphyxia and 35 cases of severe asphyxia) and 30 normal neonates(control group) were detected the values of serum cTnI and CK-MB by the microparticles chemiluminescence and dry chemical analysis.Results The average values of cTnI and CK-MB were(0.03 ± 0.02)ng/mL and(37.0±12.3)U/L for the normal control group,(0.12 ± 0.05)ng/mL and(71.0±19.3)U/L for the mild asphyxia group and(0.19 ± 0.14)ng/mL and(92.0±25.4)U/L for the severe asphyxia group.Conclusion Serum cTnI and CK-MB levels are significantly increased in neonatal asphyxia.Detecting serum cTnI and CK-MB levels can not only be used to determine the extent of myocardial damage by asphyxia,but also indirectly reflect the degree of asphyxia,which is helpful to early diagnosis and treatment.