Study on the Correlation of Transforming Growth Factor β_1 and Its Receptors with Early Recurrent Spontaneous Abortion

Objective To understand the expressions of transforming growth factor β1 (TGF -β1) and its receptors (TβR) in villi and decidua during early pregnancy and their effects on early recurrent spontaneous abortion. Methods Expressions of TGF -β1 mRNA and its receptors were detemined in villi and deciduas by semi-quantitative reverse transcriptional-polymerase chain reaction from 38 cases of spontaneous abortion women and 35 cases of normal early pregnancy women (control group). Results TGF -β1 and its receptors had expressioned in decidua cells, villis glands and interstitial cytoplasm in all two groups. The expressions of TGF-β1 in the villi and decidua of spontaneous abortion and control group were (0.18±0.02), (0.98±0.03)and (0.12±0.01), (0.72±0.02) respectively. The intensity of TβR -Ⅰ in the villi and decidua of spontaneous abortion and control groupswere (0.15±0.03), (0.71±0.01) and (0.11±0.03), (0.73±0.01) respectively. And the expressions of Tβ1R -Ⅱin the villi and decidua of spontaneous aboetion and control groups were (0.16±0.01), (0.68±0.02) and (0.09±0.01), (0.86±0.02) respectively. The differences between the control group and abortion group were all significant (P 0.01). Conclusion The expressions of TGF-β1 and its receptors in the early pregnancy tissues of aborted women declined. It demonstrates that the abnomal expressions of TGF-β1 and its receptors play an important role in spontaneous abortion, they are one of the causes of spontaneous abortion.