Clinical significance and change of α-granule membrance protein and mean platelet volume in patients with ulcerative colitis

Objective To investigate the change and clinical significance of α-granule membrane protein (GMP-140) and mean platelet volume (MPV) in patients with ulcerative colitis (UC).Methods The level of GMP-140 and MPV in 32 patients with active UC,25 patients with remissive UC and 30 normal controls were detected by ELISA technique and auto-blood analysis tester respectively.At the same time,the degree of severity of patients with active UC was evaluated.Results Compared with the normal controls and patients with remissive UC,the level of GMP-140 and MPV in patients with active UC changed significantly (P0.01).Compared with the normal controls,the two indexes in patients with remissive UC changed markedly also (P0.05).The two indexes presented markedly a tight correlation with the activity and degree of severity of UC.Conclusions The activated small volume platelets is a character of UC.The level of GMP-140 and MPV are valuable indexes in the evaluation of activity and degree of severity of UC.