Effects of butorphanol as supplement to propofol anaesthesia in painless induced abortion

Objective To evaluate efficacy and safety of butorphanol as supplement to propofol anaesthesia in painless induced abortion. Methods 60 ASA Ⅰ～Ⅱ free will pregnant women undergoing painless induced abortion were enrolled and randomly divided into treatment group(n=30)and control group(n=30).Pregnant stage was in the first or second months.In the control group,patients were administrated intravenously propofol alone;whereas in the treatment group,1mg butorphanol was used in combination with propofol.Both groups were infused intravenously by two phases,in first phase drug was used until patients were deeply sedated,in second phase(about 2～3 minuste later when uterocervical dilation)additional 50% inducing dosage was administrated.Blood pressure,heart rate,SpO2,breath frequency,revival time,propofol dosage,post-operative nausea and vomiting(PONV),vertigo and postoperative uterotonic pain(adopt VAS grade)in two groups were compared in inducing and maintaining phases.Results Data of propofol dosage,postoperative uterotonic pain and rate of breath inhibition in treated group were less than those in control group(P0.05).However,it was of no statistical significances in two groups for data of blood pressure,heart rate and SpO2.Conclusion Butophanor can reduce propofol dosage and respiratory inhibition rate,strengthen analgesia effect of propofol without more side effects when used as supplement to propofol anaesthesia in painless induced abortion.