Efficacy and safety of cilnidipine tablet in the treatment of mild to moderate hypertension

Objective To study the efficacy and safety of cilnidipine in the treatment of mild to moderate hypertension. Mehods Randomized, double blind, double modelling controlled clinical trial was conducted. Forty eignt patients were enrolled in the study, of which 24 patients in the cilnidipine group, 24 patients in the amlodipine group. Results After 8 weeks treatment, systolic and diastolic blood pressure decreased 19.26 and 14.68 mmHg(P0.01) in cilnidipine group, 18.22 and 12.91 mmHg in amlodipine group (P0.01), all of them have statistical significance. No serious adverse reaction occurred. The adverse reaction in cilnidipine and amlodipine group are 0 and 2 cases (P0.05). Conclusion Cilnidipine once daily can remarkably reduce blood pressure, no obvious adverse drug reaction occurred.