Double-blind double-dummy randomized controlled multicenter clinical trial of domestic cilnidipine on treatment of essential hypertension

Objective Evaluate the antihypertensive effects and safety of domestic cilnidipine. Methods The antihypertensive effects and safety of cilnidipine were compared with amlodipine in double-blind double-dummy randomized controlled multicenter clinical trial in 233 patients with mild to moderate essential hypertension. Results After 8 weeks of therapy, mean sitting systolic blood pressure and diastolic blood pressure were reduced by 16.2 and 12.7 mmHg, in cilnidipine 23.1 and 15.1 mmHg in amlodipine, respectively. The results showed that there was significant difference in the efficiency between cilnidipine and amlodipine (76.6% vs 87.7% ).The change of heart rates was not significant both of them. The rate of adverse effects were 16.7% in cilnidipine and 12.9% in amlodipine. The antihypertensive effects of cilnidipine could persist for long time. Conclusion Cilnidipine was effective and relatively safe for mild to moderate essential hypertension.