Acontrol study of escitalopram and shugan-jieyu capsule for therapy type 2 diabetes patients combined withmildor or moderate depression

Objective To evaluate the clinical effectiveness and safety of escitalopram and shugan-jieyu capsule for therapy T2DM(type 2 diabetes mellitus) patientswith mild or moderate depression.Methods 62 T2DM patients with mild or moderate depression according to the depression standardofICD-10 were divided into test and control group,31patients in each group,patients in control group reveived escitalopram only,10~20mg/d;patients in test group received escitalopram and shugan-jieyu capsule(0.72~1.44g/d),last for 8weeks.Assess the depression and side reaction before treatment and at the end of 1,2,4,6,8weekend by using Hamilton Depression Scale(HAMD) and Treatment Emergent Symptom Scale(TESS).Results Total effectiveness rate for test group was 93.5%,and for control group was90.3%,the differeces between the two groups present no statistically significant(P0.05).The differences of the HAMD assessment between the both groups presentno statistical significant(P 0.05).But TESS score decrease rate present statistically significant(P0.05) between the two groups atthe eighth weekend.Conclusions Escitaloptam and shugan-jieyu capsule can improve thedepression of the T2DM patients effectively,and with littleside-reaction.