2000•PubMedRequires access

[The effects of jiexinkang on the apoptosis of leukemic cells].

Cao Zh, Xie Zx, Tan Dr, Qin Q

Abstract

UNLABELLED: The effects of Chinese medicine jiexinkang(JXK) on apoptosis of leukemic cells were studied by morphology approach and electrophoresis of DNA fragments. RESULTS: 1. The apoptotic cells and apoptotic bodies were found by electrical microscopy and the typical ladders of DNA fragments were detected by electrophoresis. 2. JXK induced apoptosis of leukemic cells(HL-60 and K562) in a certain range of concentration and at appropriate time. The time to K562 cell apoptosis was longer than that of HL-60 and its dosage was larger than that of HL-60. CONCLUSION: HL-60 and K562 leukemic cell apoptosis may be induced by JXK and there is correlation between dose and time. The study provides experimental evidences for the clinical treatment of leukemia.

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Key concepts: Apoptosis, K562 cells, Leukemia, Molecular biology, DNA, Cell, Gel electrophoresis, Chemistry