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2013•The Journal of Pharmaceutical PracticeRequires access

The fingerprint analysis on Chuanshentong injection by HPLC

Junbo Xing

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Abstract

Objective To establish the fingerprint analysis for quality evaluation index of of Chuanshentong injection.Methods The fingerprints were established by HPLC.The mobile phase was acetonitrile-0.1% aqueous Formic acid solution in a gradient elution mode.The column temperature was maintained at 35 ℃.The flow rate was 1.0 ml /min,and detection wavelength was set at 281 nm.Results 11 common peaks were obtained in the fingerprint of 11 batches of Chuanshentong injection with the help of peaks match with Similarity Evaluation System for Chromatographic Fingerprint of TCM(Version 2004A).The similarity among 11 batches of Chuanshentong Injection was calculated more than 0.970.Principal components analyses was carried out to study the common HPLC fingerprint.Conclusion The method was simple,accurate and sensitive which could be used to evaluate the quality of Chuanshentong injection.

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What this paper is about

Objective To establish the fingerprint analysis for quality evaluation index of of Chuanshentong injection.Methods The fingerprints were established by HPLC.The mobile phase was acetonitrile-0.1% aqueous Formic acid solution in a gradient elution mode.The column temperature was maintained at 35 ℃.The flow rate was 1.0 ml /min,and detection wavelength was set at 281 nm.Results 11 common peaks were obtained in the fingerprint of 11 batches of Chuanshentong injection with the help of peaks match with Similarity Evaluation System for Chromatographic Fingerprint of TCM(Version 2004A).The similarity among 11 batches of Chuanshentong Injection was calculated more than 0.970.Principal components analyses was carried out to study the common HPLC fingerprint.Conclusion The method was simple,accurate and sensitive which could be used to evaluate the quality of Chuanshentong injection.

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Available abstract

Objective To establish the fingerprint analysis for quality evaluation index of of Chuanshentong injection.Methods The fingerprints were established by HPLC.The mobile phase was acetonitrile-0.1% aqueous Formic acid solution in a gradient elution mode.The column temperature was maintained at 35 ℃.The flow rate was 1.0 ml /min,and detection wavelength was set at 281 nm.Results 11 common peaks were obtained in the fingerprint of 11 batches of Chuanshentong injection with the help of peaks match with Similarity Evaluation System for Chromatographic Fingerprint of TCM(Version 2004A).The similarity among 11 batches of Chuanshentong Injection was calculated more than 0.970.Principal components analyses was carried out to study the common HPLC fingerprint.Conclusion The method was simple,accurate and sensitive which could be used to evaluate the quality of Chuanshentong injection.

Key concepts: Formic acid, Fingerprint (computing), Chromatography, High-performance liquid chromatography, Gradient elution, Chemistry, Similarity (geometry), Principal component analysis

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