Effects of breviscapin on isoproterenol-induced myocardial hypertrophy in mice

AIM:To investigate effects of Breviscapin on isoproterenol induced myocardial hypertrophy in mice.METHODS:Isoproterenol was given subcutaneously(3(mg·kg~(-1)),5 days)to induce myocardial hypertrophy in mice.Therapy group were given Breviscapin 30 minutes before ISO treatment.We investigated the cardiac weight index and the malonyldialdehyde(MDA)content,the activity of superoxide dismutase(SOD),Ca~(2+)-Mg~(2+)-ATPase in myocardium and aspartate aminotransferase(AST) in serum,Myocardiac morphological alteration was observed by micrography.RESULTS:In cardiac hypertrophy model group,HW/BW,LVW/BW(the ratio of whole heart weight to body weight and left ventricle weight to body weight),and cardiac MDA,serum AST content were increased,the activity of SOD and Ca~(2+)-Mg~(2+)-ATP ase were decreased compared with control.Breviscapin improved all the above parameters significantly and improved the left ventricular tissue morphological alteration. CONCLUSION:Breviscapine possess protective effects against Isoproterenol induced myocardial hypertrophy in mice.This may be related to reducing the oxidative stress and improving energy metabolism.