Interaction between hepatic lipase gene promoter -514C/T polymorphism and cerebral infarction

Objective To explore the interaction between hepatic lipase gene promoter -514C/T polymorphism and cerebral infarction in Shanghai Han population.Methods The genotype of the hepatic lipase gene promoter -514C/T were detected in 133 patients with cerebral infarction and 75 healthy elders using the polymerase chain reaction-restricted fragments length polymorphism technique. The effect of the gene polymorphism on serum lipid concentration were also studied. Results The significant difference was found in the frequencies of the genotypes and the alleles between cerebral infarction and healthy elders. In the group of cerebral infarction, the serum triglyceride levels in individuals with T allele were higher than those in individuals without T allele((2.21±1.45) mmol/L vs (1.68±0.72) mmol/L), but the serum high-density lipoprotein cholesterol levels were lower((1.17±0.26) mmol/L vs (1.29±0.33) mmol/L, P 0.05). The serum triglyceride levels in the group of cerebral infarction with T allele were higher than those in the group of healthy elders with T allele ((2.21±1.45) mmol/L vs (1.69±0.61) mmol/L), and the serum low-density lipoprotein cholesterol levels in the group of cerebral infarction without T allele were higher than those in the group of healthy elders without T allele ((3.30±1.00) mmol/L vs (2.87±0.82) mmol/L). Logistic regression analysis showed that systolic pressure, serum glucose and T allele were independent risk factors for cerebral infarction. Conclusion Hepatic lipase gene promoter -514C/T polymorphism is directly related to cerebral infarction. In addition, -514C/T gene polymorphism in patients with cerebral infarction may influence triglyceride and high-density lipoprotein cholesterol levels, which proves that the hyperlipemia has close relationship with some gene mutations in cerebral infarction.