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2011•Journal of Bengbu Medical CollegeRequires access

Features of immunophenotype of acute myeloid leukemia and its clinical significance

Feng Zhang

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Abstract

Objective:To investigate the characteristics and clinical significance of immunophenotype in acute myeloid leukemia(AML).Methods:Immunophenotype was carried out in 145 patients with AML using flow cytometry.Results:The expression of MPO,CD13,HLA-DR,CD33 and CD34 was 93.1%,90.3%,77.2%,71.7% and 70.3%,respectively.CD14 was expressed only in the M4 and M5 subtype.The lymphoid antigen expression was most commonly observed in CD7(34.5%),especially in M5 subtype and CD19(10.3%);CD2 was expressed only in part of M3 subtype.Two cases of acute hybrid leukemia were detected,expressing both myeloid and lymphoid associated antigen.Conclusions:MPO,CD13 and CD33 are sensitive myeloid associated antigens.The expression of CD7,CD19 and CD2,as well as the immunophenotype by flow cytometry,is of great value in diagnosis and prognosis of AML.

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Objective:To investigate the characteristics and clinical significance of immunophenotype in acute myeloid leukemia(AML).Methods:Immunophenotype was carried out in 145 patients with AML using flow cytometry.Results:The expression of MPO,CD13,HLA-DR,CD33 and CD34 was 93.1%,90.3%,77.2%,71.7% and 70.3%,respectively.CD14 was expressed only in the M4 and M5 subtype.The lymphoid antigen expression was most commonly observed in CD7(34.5%),especially in M5 subtype and CD19(10.3%);CD2 was expressed only in part of M3 subtype.Two cases of acute hybrid leukemia were detected,expressing both myeloid and lymphoid associated antigen.Conclusions:MPO,CD13 and CD33 are sensitive myeloid associated antigens.The expression of CD7,CD19 and CD2,as well as the immunophenotype by flow cytometry,is of great value in diagnosis and prognosis of AML.

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Available abstract

Objective:To investigate the characteristics and clinical significance of immunophenotype in acute myeloid leukemia(AML).Methods:Immunophenotype was carried out in 145 patients with AML using flow cytometry.Results:The expression of MPO,CD13,HLA-DR,CD33 and CD34 was 93.1%,90.3%,77.2%,71.7% and 70.3%,respectively.CD14 was expressed only in the M4 and M5 subtype.The lymphoid antigen expression was most commonly observed in CD7(34.5%),especially in M5 subtype and CD19(10.3%);CD2 was expressed only in part of M3 subtype.Two cases of acute hybrid leukemia were detected,expressing both myeloid and lymphoid associated antigen.Conclusions:MPO,CD13 and CD33 are sensitive myeloid associated antigens.The expression of CD7,CD19 and CD2,as well as the immunophenotype by flow cytometry,is of great value in diagnosis and prognosis of AML.

Key concepts: Immunophenotyping, CD33, Medicine, Myeloid leukemia, Myeloid, CD34, Flow cytometry, Leukemia

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