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2002•The Orthopedic Journal of ChinaRequires access

Expression and Clinical Significance of Immune Complexs in Herniated Lumbar Disc Tissue

Shi Ke

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Abstract

Objective: To determine whether the expression of immune complexes in the herniated disc tissue and explore the mechanism of lumbar pain and sciatica induced by herniated disc tissue.Methods:Seventy six specimens of various herniated disc tissue were immunostained with anti human IgG,using the avidin biotin peroxidase complex method.Results:IC was found in 40 of 48 (83%) extrusion and sequestration disc tissue,in only 8 of 28(29%) bulging and protrusion disc tissue.Conclusion:Immune complexes seem to be prevelence in the herniated lumbar disc tissue.This may suggest IC play an important role in pathogenesis of humbar pain and sciatica.

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Objective: To determine whether the expression of immune complexes in the herniated disc tissue and explore the mechanism of lumbar pain and sciatica induced by herniated disc tissue.Methods:Seventy six specimens of various herniated disc tissue were immunostained with anti human IgG,using the avidin biotin peroxidase complex method.Results:IC was found in 40 of 48 (83%) extrusion and sequestration disc tissue,in only 8 of 28(29%) bulging and protrusion disc tissue.Conclusion:Immune complexes seem to be prevelence in the herniated lumbar disc tissue.This may suggest IC play an important role in pathogenesis of humbar pain and sciatica.

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Available abstract

Objective: To determine whether the expression of immune complexes in the herniated disc tissue and explore the mechanism of lumbar pain and sciatica induced by herniated disc tissue.Methods:Seventy six specimens of various herniated disc tissue were immunostained with anti human IgG,using the avidin biotin peroxidase complex method.Results:IC was found in 40 of 48 (83%) extrusion and sequestration disc tissue,in only 8 of 28(29%) bulging and protrusion disc tissue.Conclusion:Immune complexes seem to be prevelence in the herniated lumbar disc tissue.This may suggest IC play an important role in pathogenesis of humbar pain and sciatica.

Key concepts: Sciatica, Medicine, Lumbar, Immune system, Intervertebral disc, Pathogenesis, Pathology, Intervertebral disk

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