Impact of Sleep Apnea on Prognosis of Patients With Congestive Heart Failure

Objective:To assess the impact of untreated sleep apnea(SA)on prognosis of patients with congestive heart failure(CHF).Methods:A total of 128 CHF patients including 105 male and 23 female were enrolled in this study.All patients met the following criteria:elder than 18 years of age,the left ventricular ejection fraction ≤0.45,and NYHA class at Ⅱ~Ⅳ.CHF patients were divided into three groups according to plysomonlography.CHF-N group,the patients without SA,n=23,CHF-OSA group,the patients combined with obstructive SA,n=55,and CHF-CSA group,the patients combined with central SA,n=50.The average follow-up time was 35 months.At the end of follow-up,we compared the mortality rate in different groups.Results:The mortality rate was significantly lower in CHF-N group than that in CHF-CSA group(6.72% vs.18.22%,P=0.017),and non-survivors showed the higher incidence of SA than the survivors(90% vs.79%,P=0.017).While multivariate analysis indicated that with the adjustment of age and body weight index,the occurrence of OSA or CSA and the severity of SA had no obvious relationship to the death of the patients with CHF.Conclusion:Untreated OSA or CSA had no obvious impact on prognosis of patients with congestive heart failure.