Observation on therapeutic effect of combined therapy of ursodeoxycholic acid capsules and ademetionine in patients with jaundice from cirrhosis

Objective To observe the therapeutic effect of combined therapy of ursodeoxycholic acid capsules(ursofalk) and ademetionine(transmetil) in patients with jaundice from cirrhosis. Methods Forty six patients of jaundice from cirrhosis were randomly divided into treatment group(n=23) and control group(n=23). Liver protection and supportive treatments were not given for the two groups. Ursodeoxycholic acid capsules[10-15mg/(kg·d), two or three times a day,for oral use] and ademetionine(Transmetil 1000mg/d intravenous drip) were given for the treatment group;the same treatments were given to the control group except ursodeoxycholic acid capsules.The treatment duration was 2 weeks in both groups.The liver function(TBIL,TBA,ALT and AST), clinical symptom and physical sign were compared before and after being treated. Results After being treated,the liver function,clinical symptom and physical sign of treatment group got better.There was significant difference between two groups(P 0.05). Conclusion The combined treatment of ursodeoxycholic acid and ademetionine could obtain better curative effect.