Clinical study of sequential treatment with Wenyang Huayu decoction and lamivudine on patients with chronic hepatitis B

Objective:In order to obstract the clinical effect of sequential using Wenyang Huayu decoction and lamivudine on the patients with chronic hepatitis B,which was in immune tolerance period.Methods:Totally 60 patients with chronic hepatitis B were randomly divided into two groups:30 cases as therapy group and 30 cases as control group.The therapy group was administered Wenyang Huayu decoction,tested liver function once a week,after serum alanine aminotransferase(ALT) up to 200U/L,then retook lamivudine tablet 100mg once daily and followed-up for 6 months.The control group were only prescribed lamivudine 100mg once daily.The liver function and hepatitis B(HBV) virology including HBV DNA level,HBV marker,and hepatic fibrosis related indexes(HA,LN,PCⅢ,Ⅳ-C)were tested at pre-therapy with Wenyang Huayu decoction,before and after 6 months treatment with lamivudine.Pathologic examination of liver biopsy were performed before and after 6 months treatment with lamivudine.Results:After Wenyang Huayu decoction was taken for 3 weeks to 3 months,the serum ALT of the therapy group had a reduction at first,then had an improvement,up as high as 5×ULN to 10×ULN.When the serum ALT of the therapy group up to 5×ULN to 10×ULN,symptoms of lacking in vital yang had improved obviously,the HA concentration of the therapy group was improved obviously,the median of the grade of inflammation of hepatic tissue was around grade 3,and was distince different from that of the control group at pre-therapy with lamivudine.After treatment with lamivudine for 6 months,the grading scores of inflammation of hepatic tissue were decreased obviously but there was indistinct different in the two groups,the rats of undetectable HBV DNA level and HBeAg/HBeAb sero-conversion were distinct different in the two group.The hepatic fibrosis related indexes(HA,LN,PCⅢ,Ⅳ-C) were indistinct different in the two groups at pre-therapy,and were distinct different after 6 months treatment with lamivudine.The fibrotic stage scores were decreased at various degrees in the two groups after 6 months treatment with lamivudine,but there was indistinct different in the two groups at before and after 6 months treatment with lamivudine.Conclusion:Wenyang Huayu decoction could break immune tolerance to HBV antigen.Significant improvement of negative rat of HBV makers,HBV DNA as well as significant decrease in hepatic fibrosis related indexes(HA,LN,PCⅢ,Ⅳ-C) could be obtained by sequential treatment with Wenyang Huayu decoction and lamivudine on patients with chronic hepatitis B than only by treatment with lamivudine.