Effects of borneol-β-cyclodextrin inclusion complex on the plasma and brain concentrations of tetramethylpyrazine phosphate in mice

Aim:To study the effects of borneol-β-cyclodextrin inclusion complex on mice plasma and brain concentrations of tetramethylpyrazine phosphate.Methods:Tetramethylpyrazine phosphate plasma and brain concentrations in mice after oral administration of tetramethylpyrazine phosphate with borneol-β-cyclodextrin inclusion complex at selected intervals were determined by GC-FID.The pharmacokinetic parameters were estimated by the program 3P97.Results:Both tetramethylpyrazine phosphate plasma and brain concentration-time courses in mice were best fitted to open two-compartment model with first-order absorption.No changes to in vivo behavior of tetramethylpyrazine phosphate in the presence of borneol-β-cyclodextrin inclusion complex.Furthermore,borneol-β-cyclodextrin inclusion complex resulted in less enhancement in the oral absorption of tetramethylpyrazine phosphate and tetramethylpyrazine phosphate levels in brain tissue than did borneol alone.Conclusion:Borneol material or other borneol dosages rather than β-cyclodextrin inclusion complex is more fitted to the Chinese medicines containing borneol.